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Assay Interferences are a common problem in the laboratory, creating a disconnect between the test result and the clinical reality. This forces the lab to investigate, to handle samples as exceptions, which interrupts the workflow and creates a delay in the test result.
Up to 5% of Clinical Laboratory test results are potentially affected as a result of the common interferences.*
Assay design plays a critical role in enabling the correct diagnosis and corresponding treatment path. VITROS® Solutions offer safety technologies to minimize these problems, increasing efficiency and quality of laboratory test results as well as Turn around Time, which is crucially important for critically ill patients.
Learn here how this is being addressed for 5 common challenges:
How to assure the right result for electrolytes also at abnormal levels of proteins/lipids?
With Indirect ISE, Samples are diluted. Samples with increased fraction of solid phase result in a more dilute liquid phase and the concentration of electrolyte is underestimated.
Other advantages:
How to avoid falsely reported results due to Hemolysis, Icterus or Lipemia (HIL)
% OF SAMPLES WITH HIL
(average based on multiple references*)
6%
Hemolysis
7.6%
Icterus
7.4%
Lipemia
Spreading layer filters out the potentially interfering hemoglobine, bilirubines or lipids for chemistry assays.
Flags results in case of endogenous interferences for homo- and heterogenous immunoassays with:
How To Avoid Falsely Elevated Or Decreased Results On A Variety Of Assays Due To Paraproteins.
The overall prevalence of paraproteinemia has not been rigorously studied; however, the prevalence of MGUS, the most common cause of paraproteinemia, is approximately 3-4% in individuals > 50 years old and 6-8% for those individuals >80 years old. 1
Paraproteins present in serum can interfere in a variety of ways with a number of laboratory assays, leading to a range of incorrect laboratory results.
How To Avoid Erroneous Results Due To Bad Water Quality?
The table below provides an overview of the different contaminants that can impact laboratory applications.3
IONS | ORGANICS | BACTERIA | BACTERIA by-products | PARTICLES | SILICA | |
---|---|---|---|---|---|---|
General Chemistry | x | x | ||||
Enzymes | x | x | x | x | ||
Toxicology TDM | x | x | x | |||
EIA | x | x | x | x | ||
Trace Elements | x | x | x | x | ||
Molecular Testing | x | x | x | x | ||
Diagnostic Instruments | x | x | x | x | x | x |
How To Avoid Errors Due to Bubbles and Clots and Avoid Carry Over?
Patented Pressure Level-Sensing technology for bubble and clot detection.
References
* Data on file PR-05255.
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